Gatifloxacin Impurity 36 CAS 1048972-69-5 (free base)
| CAS No. | 1048972-69-5 (free base) |
| Molecular Formula | C19H22FN3O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Gatifloxacin Impurity 36 (CAS 1048972-69-5 (free base)), a pharmacopoeial impurity reference standard (molecular formula C19H22FN3O4HCl, MW 411.86 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Gatifloxacin Impurity 36 (C19H22FN3O4HCl) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H22FN3O4 HCl |
| Molecular Weight | 411.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Gatifloxacin Standards
- Gatifloxacin USP RC E (CAS 1029364-65-5)
- Gatifloxacin USP RC E sodium (CAS 1029364-65-5 (acid))
- Gatifloxacin Impurity 13 (CAS 103460-87-3)
- Gatifloxacin Impurity 4 (CAS 103460-89-5)
- Gatifloxacin Impurity 17 (CAS 1048972-28-6)
- Gatifloxacin Impurity 18 (CAS 1048972-69-5)
- Gatifloxacin Related Compound D(3-Desmethyl Gatifloxacin) (CAS 112811-57-1)
- Gatifloxacin Impurity 23 (CAS 112811-58-2)
Recommended Standards
- Bosutinib Impurity 1 (CAS 1391063-17-4)
- Ozefloxacin Impurity 11 (CAS CATO-C4X-279611)
- Cefprozil Impurity 47 (CAS CATO-C4X-149247)
- Calmagite triethanolammonium salt (CAS 91698-30-5)
- 8-Methyl-N-(prop-2-yn-1-yl)-8-azabicyclo[3.2.1]octan-3-amine (CAS 1132901-83-7)
- 4-(4-Bromophenyl)-2-(cyclohexylamino)-4-oxobutanoic acid (CAS 1031263-33-8)
- 2-(3,4-Dihydro-1h-2-benzopyran-6-yl)acetic acid (CAS 933694-72-5)
- 3,4-Dihydroxybenzohydrazide (CAS 39635-11-5)
- 2-Hydroxyethyl Methanethiosulfonate (CAS 13700-08-8)
- Steroidogenesis-Activator Polypeptide (rat) (H-8855.0500) (CAS 108563-23-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com